Customer Academic Publications

Gene Synthesis

Huang, J., Zha, W., An, T. et al. Appl Microbiol Biotechnol (2019) 103: 7029. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid doi:10.1007/s00253-019-10004-z

Wang, Z.-P.; Zhang, L.-L.; Liu, S.; Liu, X.-Y.; Yu, X.-J. Whole Conversion of Soybean Molasses into Isomaltulose and Ethanol by Combining Enzymatic Hydrolysis and Successive Selective Fermentations. Biomolecules 2019, 9, 353. doi: 10.3390/biom9080353

Moog, D., Schmitt, J., Senger, J. et al. Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation Microb Cell Fact (2019) 18: 171.doi:10.1186/s12934-019-1220-z

Proietti, S.; Falconieri, G.S.; Bertini, L.; Baccelli, I.; Paccosi, E.; Belardo, A.; Timperio, A.M.; Caruso, C. GLYI4 Plays A Role in Methylglyoxal Detoxification and Jasmonate-Mediated Stress Responses in Arabidopsis thaliana. Biomolecules 2019, 9, 635 doi:10.3390/biom9100635

Xu Y , Li Y , Zhang L , et al. Unraveling the specific regulation of the shikimate pathway for tyrosine accumulation in Bacillus licheniformis[J]. Journal of Industrial Microbiology and Biotechnology, 2019, 46(8). doi:10.1007/s10295-019-02213-2

Chen Y J, Zhang J, Zhu P P, et al. Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-hydroxylation is an In Vitro Marker of CYP3A7 Activity[J]. Drug Metabolism and Disposition, 2019: dmd. 119.086637. doi:10.1124/dmd.119.086637

Jiang S, Jiang H, Zhou Y, et al. High-level expression of β-N-Acetylglucosaminidase BsNagZ in Pichia pastoris to obtain GlcNAc[J]. Bioprocess and biosystems engineering, 2019, 42(4): 611-619. doi:10.1007/s00449-018-02067-5

Li S Y, Wang Z P, Wang L N, et al. Combined enzymatic hydrolysis and selective fermentation for green production of alginate oligosaccharides from Laminaria japonica[J]. Bioresource technology, 2019, 281: 84-89. doi:10.1016/j.biortech.2019.02.056

Zhang F, Wang W, Bah F B M, et al. Heterologous Expression of a Thermostable α-Glucosidase from Geobacillus sp. Strain HTA-462 by Escherichia coli and Its Potential Application for Isomaltose–Oligosaccharide Synthesis[J]. Molecules, 2019, 24(7): 1413. doi:10.3390/molecules24071413

Orlomoski R, Bogle A, Loss J, et al. Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization[J]. Protein expression and purification, 2019, 158: 9-14. doi:10.1016/j.pep.2019.02.001

Su Y, Han M, Meng X, et al. Discovery and characterization of a novel C-terminal peptide carboxyl methyltransferase in a lassomycin-like lasso peptide biosynthetic pathway[J]. Applied microbiology and biotechnology, 2019: 1-16. doi:10.1007/s00253-019-09645-x

Zhou L, Sheng D, Wang D, et al. Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay[J]. Cell biology and toxicology, 2019, 35(2): 161-177. doi:10.1007/s10565-018-9444-y

Wanitchang A, Saenboonrueng J, Kaewborisuth C, et al. A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 Cells[J]. Viruses, 2019, 11(3): 282. doi:10.3390/v11030282

Zhang P, Wang Z P, Liu S, et al. Overexpression of secreted sucrose isomerase in Yarrowia lipolytica and its application in isomaltulose production after immobilization[J]. International journal of biological macromolecules, 2019, 121: 97-103. doi:10.1016/j.ijbiomac.2018.10.010

Liu H, Chen D, Bi J, et al. Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer[J]. Aging (Albany NY), 2018, 10(10): 2606. doi:10.18632/aging.101573

Yao Y, Li S, Cao J, et al. A novel signal transduction system for development of uric acid biosensors[J]. Applied microbiology and biotechnology, 2018, 102(17): 7489-7497. doi:10.1007/s00253-018-9056-8

Wanitchang A, Saenboonrueng J, Srisutthisamphan K, et al. Characterization of influenza A virus pseudotyped with the spike protein of porcine epidemic diarrhea virus[J]. Archives of virology, 2018, 163(12): 3255-3264. doi:10.1007/s00705-018-4001-9

Wu Y, Jiang Y, Zheng X, et al. Facile fabrication of microfluidic surface-enhanced Raman scattering devices via lift-up lithography[J]. Royal Society open science, 2018, 5(4): 172034. doi:10.1098/rsos.172034

Gong, S., & Wu, C. (2019, February 1). Generation of Fabs-in-tandem immunoglobulin molecules for dual-specific targeting. Methods,154, 87-92. doi:10.1016/j.ymeth.2018.07.014

Eastwood M P, Deprest J, Russo F M, et al. MicroRNA 200b is upregulated in the lungs of fetal rabbits with surgically induced diaphragmatic hernia[J]. Prenatal diagnosis, 2018, 38(9): 645-653. doi:10.1002/pd.5318

Johnston C D, Cotton S L, Rittling S R, et al. SyngenicDNA: stealth-based evasion of restriction-modification barriers during bacterial genetic engineering[J]. bioRxiv, 2018: 387985. doi:10.1101/387985

Lu H, Bai Y, Fan T, et al. Identification of a L-Lactate dehydrogenase with 3, 4-dihydroxyphenylpyruvic reduction activity for L-Danshensu production[J]. Process Biochemistry, 2018, 72: 119-123. doi:10.1016/j.procbio.2018.06.011

Chu J, Li Y, Fan X, et al. MiR-4319 suppress the malignancy of triple-negative breast cancer by regulating self-renewal and tumorigenesis of stem cells[J]. Cellular Physiology and Biochemistry, 2018, 48(2): 593-604. doi:10.1159/000491888

Peng C, Liu Y, Guo X, et al. Selective carboxylation of substituted phenols with engineered Escherichia coli whole-cells[J]. Tetrahedron letters, 2018, 59(42): 3810-3815. doi:10.1016/j.tetlet.2018.09.019

Hu X X, Xu X N, He B S, et al. microRNA-485-5p functions as a tumor suppressor in colorectal cancer cells by targeting CD147[J]. Journal of Cancer, 2018, 9(15): 2603. doi:10.7150/jca.24918

Chang, Z., Meng, F., Zhang, Z., Mao, G., Huang, Z., Liao, W., & He, A. (2018). MicroRNA-193b-3p regulates matrix metalloproteinase 19 expression in interleukin-1β-induced human chondrocytes. Journal of Cellular Biochemistry,119(6), 4775-4782. doi:10.1002/jcb.26669

Cheng, Y., Chen, G., Wang, L., Kong, J., Pan, J., Xi, Y., . . . Huang, Z. (2018). Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells. Toxicology Letters,292, 136-150. doi:10.1016/j.toxlet.2018.04.035

Hu, X., Xu, X., He, B., Sun, H., Xu, T., Liu, X., . . . Pan, Y. (2018). MicroRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147. Journal of Cancer,9(15), 2603-2611. doi:10.7150/jca.24918

Jin, W., Li, S., Chen, J., Liu, B., Li, J., Li, X., . . . Zhong, W. (2018). Increased soluble heterologous expression of a rat brain 3- O -sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification,151, 23-29. doi:10.1016/j.pep.2018.06.007

Li, J., Zhang, Y., Zhang, Y., Lü, S., Miao, Y., Yang, J., . . . Feng, J. (2018). GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation. Redox Biology,17, 386-399. doi:10.1016/j.redox.2018.04.021

Pan, Y., Sun, H., Hu, X., He, B., Liu, X., Xu, T., . . . Wang, S. (2018). The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147. Oncology Reports. doi:10.3892/or.2018.6309

Peng, C., Liu, Y., Guo, X., Liu, W., Li, Q., & Zhao, Z. K. (2018, October 17). Selective carboxylation of substituted phenols with engineered Escherichia coli whole-cells. Tetrahedron Letters,59(42), 3810-3815. doi:10.1016/j.tetlet.2018.09.019

Shi, J., Wang, X., Zhu, H., Jiang, H., Wang, D., Nesvizhskii, A., & Zhu, H. (2018, August 24). Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method. Journal of Proteome Research,17(10), 3606-3612. doi:10.1021/acs.jproteome.8b00620

Shi, J., Wang, X., Zhu, H., Jiang, H., Wang, D., Nesvizhskii, A., & Zhu, H. (2018). Determining Allele-Specific Protein Expression (ASPE) Using a QconCAT-Based Proteomics Method: A Novel Approach to Identify Cis-acting Genetic Variants. doi:10.1101/264614

Lu, H., Bai, Y., Fan, T., Zhao, Y., Zheng, X., & Cai, Y. (2018). Identification of a l -Lactate dehydrogenase with 3,4-dihydroxyphenylpyruvic reduction activity for l -Danshensu production. Process Biochemistry,72, 119-123. doi:10.1016/j.procbio.2018.06.011

Yang, X., Sun, W., Shen, H., Zhang, S., Jiao, X., & Zhao, Z. K. (2018). Expression of phosphotransacetylase in Rhodosporidium toruloides leading to improved cell growth and lipid production. RSC Advances,8(43), 24673-24678. doi:10.1039/c8ra03028f

Zhang, W., He, Z., Yi, L., Mao, S., Li, H., & Lin, J. (2018). A dual-functional microfluidic chip for on-line detection of interleukin-8 based on rolling circle amplification. Biosensors and Bioelectronics,102, 652-660. doi:10.1016/j.bios.2017.12.017

Wang, J., Chen, S., Xiao, W., Li, W., Wang, L., Yang, S., . . . Zhou, P. (2018, January 10). CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia. Journal of Hematology & Oncology,11(1). doi:10.1186/s13045-017-0553-5

Zhao, Z., Xue, J., Song, Y., Liu, T., & Piao, D. (2017). Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells. Oncology Letters. doi:10.3892/ol.2017.6977

Wang, L., Liang, C., Wu, J., Liu, L., & Tyo, K. E. (2017). Increased Processivity, Misincorporation, and Nucleotide Incorporation Efficiency in Sulfolobus solfataricus Dpo4 Thumb Domain Mutants. Applied and Environmental Microbiology,83(18). doi:10.1128/aem.01013-17

Wang, X., Zhou, Y. J., Wang, L., Liu, W., Liu, Y., Peng, C., & Zhao, Z. K. (2017). Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis. Applied and Environmental Microbiology,83(13). doi:10.1128/aem.00692-17

Wang, X., Wang, L., Lin, X., Yang, X., Liu, W., & Zhao, Z. K. (2017). Visualizing Soluble Protein Mutants by Using Monomeric Red Fluorescent Protein as a Reporter for Directed Evolution. Applied Biochemistry and Biotechnology,185(1), 81-90. doi:10.1007/s12010-017-2640-z

Xie, Z., Liu, D., Li, B., Zhao, M., Zeng, B., Wu, Y., . . . Yuan, Y. (2017). Design and chemical synthesis of eukaryotic chromosomes. Chemical Society Reviews,46(23), 7191-7207. doi:10.1039/c7cs00208d

Liu, J., Chen, W., Zhang, H., Liu, T., & Zhao, L. (2017). MiR‑214 targets the PTEN‑mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Oncology Letters. doi:10.3892/ol.2017.6953

Dai, S., Zhang, J., Huang, S., Lou, B., Fang, B., Ye, T., . . . Zhou, M. (2017). HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer Cell International,17(1). doi:10.1186/s12935-016-0368-4

Duan, L., Ding, W., Liu, X., Cheng, X., Cai, J., Hua, E., & Jiang, H. (2017). Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae. Microbial Cell Factories,16(1). doi:10.1186/s12934-017-0774-x

He, P., Li, Y., Luo, J., Wang, H., Yan, Y., & Chen, Z. (2017). Development and Application of A Duplex Real-Time RT-PCR Assay for Simultaneous Detection of Coxsackievirus A6 and Coxsackievirus A10. Ann Clin Lab Sci,47(March), 2nd ser., 178-183. PMID: 28442520

Jin, L., Miao, J., Liu, Y., Li, X., Jie, Y., Niu, Q., & Han, X. (2017). Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. Biomedicine & Pharmacotherapy,85, 287-295. doi:10.1016/j.biopha.2016.11.023

Su, J., Gao, J., Si, Y., Cui, L., Song, C., Wang, Y., . . . Zhou, Y. (2017, March). Galectin-10: A new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology,28(3), 159-168. doi:10.1093/glycob/cwx107

Li, N., Yi, L., He, Z., Zhang, W., Li, H., & Lin, J. (2017). A DNA-directed covalent conjugation fluorescence probe for in vitro detection of functional matrix metalloproteinases. The Analyst,142(4), 634-640. doi:10.1039/c6an02339h

Si Y, Wang Y, Gao J, et al. Crystallization of galectin-8 linker reveals intricate relationship between the N-terminal tail and the linker[J]. International journal of molecular sciences, 2016, 17(12): 2088. doi:10.3390/ijms17122088

Li, Z., Feng, S., Zhou, L., Liu, S., & Cheng, J. (2016). NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. Biochemical and Biophysical Research Communications,475(1), 133-139. doi:10.1016/j.bbrc.2016.05.056

Na, R., Jiajia, L., Dongliang, Y., Yingzi, P., Juan, H., Xiong, L., . . . Yitian, L. (2016). Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum , Apocynaceae. Microbiological Research,192, 114-121. doi:10.1016/j.micres.2016.06.008

Pan, X., Wang, H., Tong, D., Wang, C., Sun, L., Zhao, C., . . . Wu, D. (2016). Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370. Am J Cancer Res,6(Dec), 12th ser., 2919-2931. PMID: 28042511

Si, X., Zhang, X., Hao, X., Li, Y., Chen, Z., Ding, Y., . . . Zhou, Y. (2016). Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion. Oncotarget,7(47). doi:10.18632/oncotarget.12947

Tang, Y., Cui, Y., Li, Z., Jiao, Z., Zhang, Y., He, Y., . . . Zhang, S. (2016). Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. Journal of Experimental & Clinical Cancer Research,35(1). doi:10.1186/s13046-016-0285-3

Yang, H., Zhu, Q., Zhou, N., & Tian, Y. (2016). Optimized expression of prolyl aminopeptidase in Pichia pastoris and its characteristics after glycosylation. World Journal of Microbiology and Biotechnology,32(11). doi:10.1007/s11274-016-2135-z

Gene Cloning

Campanella J J, Kurdach S, Skibitski R, et al. Evidence for the Early Evolutionary Loss of the M20D Auxin Amidohydrolase Family from Mosses and Horizontal Gene Transfer from Soil Bacteria of Cryptic Hydrolase Orthologues to Physcomitrella patens[J]. Journal of Plant Growth Regulation, 2019: 1-11. doi:10.1007/s00344-019-09945-6

Hu, J., Tian, J., Li, F., Xue, B., Hu, J., Cheng, X., . . . Li, B. (2017). Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Scientific Reports,7(1). doi:10.1038/srep41563

Yan, H., Zhang, Y., Zhang, Y., Ren, X., Shen, Y., Cheng, M., & Zhang, Y. (2017). CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. Biochimica Et Biophysica Acta (BBA) – Gene Regulatory Mechanisms,1860(4), 516-522. doi:10.1016/j.bbagrm.2017.02.006

Codon Optimization

Zhang P, Wang Z P, Sheng J, et al. High and efficient isomaltulose production using an engineered Yarrowia lipolytica strain[J]. Bioresource technology, 2018, 265: 577-580. doi:10.1016/j.biortech.2018.06.081

Liu, B., Kong, Q., Zhang, D., & Yan, L. (2018). Codon optimization significantly enhanced the expression of human 37-kDa iLRP in Escherichia coli. 3 Biotech,8(4). doi:10.1007/s13205-018-1234-y

Jin, W., Li, S., Chen, J., Liu, B., Li, J., Li, X., . . . Zhong, W. (2018). Increased soluble heterologous expression of a rat brain 3- O -sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification,151, 23-29. doi:10.1016/j.pep.2018.06.007

Zhang, P., Wang, Z., Sheng, J., Zheng, Y., Ji, X., Zhou, H., . . . Chi, Z. (2018). High and efficient isomaltulose production using an engineered Yarrowia lipolytica strain. Bioresource Technology,265, 577-580. doi:10.1016/j.biortech.2018.06.081


Zhu M , Sun L , Lu X , et al. Establishment of a transient CRISPR-Cas9 genome editing system in Candida glycerinogenes for co-production of ethanol and xylonic acid[J]. Journal of Bioscience and Bioengineering, 2019.doi:10.1016/j.jbiosc.2019.03.009

Li J, Chen Z, Chen F, et al. Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein[J]. bioRxiv, 2019: 614859. doi:10.1101/614859

Zheng S, Liu Q, Ma R, et al. Let‐7b‐5p inhibits proliferation and motility in squamous cell carcinoma cells through negative modulation of KIAA1377[J]. Cell biology international, 2019. doi:10.1002/cbin.11136

Oligo Synthesis

Y Li , X Wang , J Li , Y Wang, J Song … J Zhao (2019)Effects of struvite-humic acid loaded biochar/bentonite composite amendment on Zn(II) and antibiotic resistance genes in manure-soil Chemical Engineering JournalVolume 375, 1 November 2019, doi:10.1016/j.cej.2019.122013

H Zhang , J Sun , Y Yan , 1, S Cui , H Wang, Cheng H ,Wang… Q Zhang (2019)Encapsulated microRNA by gemcitabine prodrug for cancer treatment Journal of Controlled Release Volume 316, 28 December 2019, Pages 317-330 doi:10.1016/j.jconrel.2019.11.010

Chen, M; Wu, Y2; Yu, S; Liu, S; Wang, Y; Huang, D; Xu, X; Lin, F(2019)Drug Resistance and Integron Genes in Escherichia coli Isolated from Urinary Tract Infection Journal of Nanoscience and Nanotechnology, Volume 19, Number 9, September 2019, pp. doi:10.1166/jnn.2019.16501

Zhou S, Tao M, Wang Y, et al. Effects of CYP3A4* 1G and CYP3A5* 3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects[J]. Xenobiotica, 2019, 49(3): 375-380. doi:10.1002/bies.950050611

He Q, Zhu S, Lin M, et al. Increased GPR120 level is associated with gestational diabetes mellitus[J]. Biochemical and biophysical research communications, 2019. doi:10.7150/ijbs.31009

Nan M, Bi Y, Xue H, et al. Rapid Determination of Ochratoxin A in Grape and Its Commodities Based on a Label-Free Impedimetric Aptasensor Constructed by Layer-by-Layer Self-Assembly[J]. Toxins, 2019, 11(2): 71. doi:10.3390/toxins11020071

Wang Z, Fang J, Xiao J. Correlation of the expression of inflammatory factors with expression of apoptosis-related genes Bax and Bcl-2, in burned rats[J]. Experimental and therapeutic medicine, 2019, 17(3): 1790-1796. doi:10.3892/etm.2018.7118

Liu X, Zhang Y, Liu H, et al. RNA interference in the oleaginous yeast Rhodosporidium toruloides[J]. FEMS yeast research, 2019. doi:10.1093/femsyr/foz031

Huang X, Xue J, Wang F Z, et al. Enhanced protoplast assay by transfecting PCR-assembled gene expression cassettes with telomeric repeats and thiophosphate modifications[J]. Analytical biochemistry, 2019, 569: 39-45. doi:10.1016/j.ab.2019.01.003

Wang J, Huang J, Zhu M, et al. Osteopontin potentiates PM-induced IL-1α and IL-1β production via the ERK/JNK signaling pathway[J]. Ecotoxicology and environmental safety, 2019, 171: 467-474. doi:10.1016/j.ecoenv.2019.01.005

He Q, Zhu S, Lin M, et al. Increased GPR120 level is associated with gestational diabetes mellitus[J]. Biochemical and biophysical research communications, 2019. doi:10.1016/j.bbrc.2019.03.034

Chen M, Wu Y, Yu S, et al. Drug Resistance and Integron Genes in Escherichia coli Isolated from Urinary Tract Infection[J]. Journal of nanoscience and nanotechnology, 2019, 19(9): 5989-5993. doi:10.1166/jnn.2019.16501

Wang, J., Zhu, M., Wang, L., Chen, C., & Song, Y. (2019). Amphiregulin potentiates airway inflammation and mucus hypersecretion induced by urban particulate matter via the EGFR-PI3Kα-AKT/ERK pathway. Cellular Signalling,53, 122-131. doi:10.1016/j.cellsig.2018.10.002

Li X, Huang X, Zhang J, et al. A novel peptide targets CD105 for tumour imaging in vivo[J]. Oncology reports, 2018, 40(5): 2935-2943. doi:10.3892/or.2018.6643

Shen P, Chen J, Pan M. The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway[J]. Molecular medicine reports, 2018, 18(3): 3332-3340. doi:10.3892/mmr.2018.9335

Cheng Y, Chen G, Wang L, et al. Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells[J]. Toxicology letters, 2018, 292: 136-150. doi:10.1016/j.toxlet.2018.04.035

Chen, S., Yang, J., Zhang, Y., Duan, C., Liu, Q., Huang, Z., . . . Xu, G. (2018). Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. Journal of Biological Chemistry,293(29), 11296-11309. doi:10.1074/jbc.ra117.001432

Fang, B., Chen, X., Wu, M., Kong, H., Chu, G., Zhou, Z., . . . Chen, B. (2018). Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia. Molecular Medicine Reports. doi:10.3892/mmr.2018.9250

Nie, H., Nie, D., & Men, L. (2018). Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Oncology Letters. doi:10.3892/ol.2018.9521

Sun, Y., Zou, H., Yang, L., Zhou, M., Shi, X., Yang, Y., . . . Lu, Y. (2018). Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression. Oncology Letters. doi:10.3892/ol.2018.8774

Zhang, H., Zhang, Z., Jia, L., Ji, W., & Li, H. (2018). Genetic Polymorphism in the RYR1 C6487T Is Associated with Severity of Hypospadias in Chinese Han Children. BioMed Research International,2018, 1-7. doi:10.1155/2018/7397839

Wang, J., Wang, F., Zhu, J., Song, M., An, J., & Li, W. (2018). Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy. Journal of Molecular Neuroscience,65(1), 102-109. doi:10.1007/s12031-018-1066-6

Zhang, Y., Pan, C., Wang, J., Cao, J., Liu, Y., Wang, Y., & Zhang, L. (2017). Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget,8(47). doi:10.18632/oncotarget.19653

Zhang, Z., Liu, Y., Liu, P., Yang, L., Jiang, X., Luo, D., & Yang, D. (2017). Non-invasive detection of gastric cancer relevant d-amino acids with luminescent DNA/silver nanoclusters. Nanoscale,9(48), 19367-19373. doi:10.1039/c7nr07337b

Yu, D., Ye, T., Xiang, Y., Shi, Z., Zhang, J., Lou, B., . . . Zhou, M. (2017). Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. OncoTargets and Therapy,Volume 10, 4719-4729. doi:10.2147/ott.s136840

Wang, J., Huang, J., Wang, L., Chen, C., Yang, D., Jin, M., . . . Song, Y. (2017). Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway. Journal of Thoracic Disease,9(11), 4398-4412. doi:10.21037/jtd.2017.09.135

Wang, Q., Wang, Y., Xing, Y., Yan, Y., Guo, P., Zhuang, J., . . . Zhang, J. (2016). Physcion 8- O -β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells. Biomedicine & Pharmacotherapy,83, 372-380. doi:10.1016/j.biopha.2016.06.045

Probe Synthesis

Mei J, Yan T, Huang Y, et al. A DAAM1 3′-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axis[J]. Cancer Cell International, 2019, 19(1): 55. doi:10.1186/s12935-019-0747-8

Eastwood, M. P., Deprest, J., Russo, F. M., Wang, H., Mulhall, D., Iwasiow, B., . . . Keijzer, R. (2018). MicroRNA 200b is upregulated in the lungs of fetal rabbits with surgically induced diaphragmatic hernia. Prenatal Diagnosis,38(9), 645-653. doi:10.1002/pd.5318

Wu, Y., Li, X., Tan, X., Feng, D., Yan, J., Zhang, H., . . . Han, H. (2018). A cyclic catalysis enhanced electrochemiluminescence aptasensor based 3D graphene/photocatalysts Cu 2 O-MWCNTs. Electrochimica Acta,282, 672-679. doi:10.1016/j.electacta.2018.06.104


S Li, Z Wang, L Wang …S Zhao (2019)Combined enzymatic hydrolysis and selective fermentation for green production of alginate oligosaccharides from Laminaria japonica Bioresource Technology Volume 281, June 2019, Pages 84-89 doi:10.1016/j.biortech.2019.0

X Zhang, L Sun, M Li, …Y Ma, C Wang, S Huang,M Ma(2019)Identification of the Novel Host Protein Interacting With the Structural Protein VP1 of Chinese Sacbrood Virus by Yeast Two-Hybrid Screening Front. Microbiol.doi:10.3389/fmicb.2019.02192

Fei Z, Li S, Wang J, et al. Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo[J]. Drug delivery, 2019, 26(1): 51-62. doi:10.1080/10717544.2018.1551439

Chen, M., Zhai, J., Liu, Y., Xue, B., Hu, J., Cheng, X., . . . Li, B. (2018). Molecular cloning and characterization of C 1 tetrahydrofolate (C 1 -THF) synthase in Bombyx mori , silkworm. Gene,663, 25-33. doi:10.1016/j.gene.2018.04.037

Yang, F., Guo, L., Lyu, K., Zhang, J., Yang, Y., Wang, H., . . . Huo, Y. (2018). Local Polyploidy Phenomenon inEscherichia coliand its significance in genetic engineering. doi:10.1101/335448

Cheng, H., Luo, Z., Lu, M., Gao, S., & Wang, S. (2017). The hyperthermophilic α-amylase from Thermococcus sp. HJ21 does not require exogenous calcium for thermostability because of high-binding affinity to calcium. Journal of Microbiology,55(5), 379-387. doi:10.1007/s12275-017-6416-5

Tang, X., Li, P., Zhang, Q., Zhang, Z., Zhang, W., & Jiang, J. (2017). Time-Resolved Fluorescence Immunochromatographic Assay Developed Using Two Idiotypic Nanobodies for Rapid, Quantitative, and Simultaneous Detection of Aflatoxin and Zearalenone in Maize and Its Products. Analytical Chemistry,89(21), 11520-11528. doi:10.1021/acs.analchem.7b02794

Vector Construction

Julien R,Marie G,Alain M (2019).Identification of a crucial amino acid implicated in the hydroxylation/desaturation ratio of CpFAH12 bifunctional hydroxylase.Biotechnology and Bioengineering ,Pages 2451-2462 doi:10.1002/bit.27102

S Hu, G Mao, Z Zhang, P Wu, X Wen, W Liao, Z Zhang(2019).MicroRNA-320c inhibits development of osteoarthritis through downregulation of canonical Wnt signaling pathway Life Sciences, Pages 242-250 doi:10.1016/j.lfs.2019.05.011

He X, Meng F, Qin L, Liu Z, Zhu X, Yu Z, Zheng Y(2019).KLK11 suppresses cellular proliferation via inhibition of Wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma. Am J Cancer Res. 2019; 9(10): 2264–2277. PMID: 31720087

Li, J., He, J., Wang, Y., Shu, Y., & Zhou, J. (2019). SMC1 promotes proliferation and inhibits apoptosis through the NF‑κB signaling pathway in colorectal cancer. Oncology Reports, 42, 1329-1342. doi:10.3892/or.2019.7273

Wu Y, Deng Y, Zhu J, et al. Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYc in ovarian cancer[J]. OncoTargets and therapy, 2018, 11: 6647. doi:10.2147/OTT.S180520

Bellido, F., Sowada, N., Mur, P., Lázaro, C., Pons, T., Valdés-Mas, R., . . . Valle, L. (2018). Association Between Germline Mutations in BRF1 , a Subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer. Gastroenterology,154(1). doi:10.1053/j.gastro.2017.09.005

Chu, J., Li, Y., Fan, X., Ma, J., Li, J., Lu, G., . . . Yuan, H. (2018). MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. Cellular Physiology and Biochemistry,48(2), 593-604. doi:10.1159/000491888

Xu, X., Song, C., Chen, Z., Yu, C., Wang, Y., Tang, Y., & Luo, J. (2018). Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18. Cancer Research and Treatment,50(1), 71-87. doi:10.4143/crt.2017.013

DNA Storage

Wang, Q.,Sun, J., Diao, W., et al. Digital Information Storage on DNA in Living Organisms. Medical Research Archives. vol 7, issue 6. June 2019. doi:10.18103/mra.v7i6.1930

Zhong, Y., Qi, S., Sheng, F., Tian, J., Zhu, P., Yang, P., & Cai, X. (2017). A new digital information storing and reading system based on synthetic DNA. Science China Life Sciences,61(6), 733-735. doi:10.1007/s11427-017-9131-7

RNA Interference

Ren, Y., Chen, J., Wu, X., Gui, C., Mao, K., Zou, F., & Li, W. (2018). Role of c-Abl-GSK3β Signaling in MPP -Induced Autophagy-Lysosomal Dysfunction. Toxicological Sciences,165(1), 232-243. doi:10.1093/toxsci/kfy155

RNA Synthesis

Wang L, Song L, Li J, et al. Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone. Cancer Sci. 2019;110:3157–3172. doi:10.1111/cas.14172

Zhang C, Zhang Z, Chang Z, et al. miR‐193b‐5p regulates chondrocytes metabolism by directly targeting histone deacetylase 7 in interleukin‐1β‐induced osteoarthritis[J]. Journal of cellular biochemistry, 2019. doi:10.1002/jcb.28545

Peng J, Zhou F, Wang Y, et al. Differential response to lead toxicity in rat primary microglia and astrocytes[J]. Toxicology and applied pharmacology, 2019, 363: 64-71. doi:10.1016/j.taap.2018.11.010

Feng Q, Yang W, Gao Z, et al. Up-regulation of P-gp via NF-κB activation confers protection against oxidative damage in the retinal pigment epithelium cells[J]. Experimental eye research, 2019, 181: 367-373. doi:10.1016/j.exer.2018.11.024

Du K T, Deng J Q, He X G, et al. MiR-214 regulates the human hair follicle stem cell proliferation and differentiation by targeting EZH2 and Wnt/β-catenin signaling way in vitro[J]. Tissue engineering and regenerative medicine, 2018, 15(3): 341-350. doi:10.1007/s13770-018-0118-x

Chang Z, Meng F, Zhang Z, et al. MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes[J]. Journal of cellular biochemistry, 2018, 119(6): 4775-4782. doi:10.1002/jcb.26669

Plasmid Preparation

Dong H, Cao W, Xue J. Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1[J]. Biochemical and biophysical research communications, 2019, 508(4): 1074-1081.2018. doi:10.1016/j.bbrc.2018.12.050

Sayas C L, Medina M, Cuadros R, et al. Role of tau N-terminal motif in the secretion of human tau by end binding proteins[J]. PloS one, 2019, 14(1): e0210864. doi:10.1371/journal.pone.0210864

Ho N T T, Kutzner A, Heese K. A Novel Divergent Gene Transcription Paradigm—the Decisive, Brain-Specific, Neural|-Srgap2–Fam72a-| Master Gene Paradigm[J]. Molecular neurobiology, 2019: 1-9. doi:10.1007/s12035-019-1486-5

Bellido F, Sowada N, Mur P, et al. Association between germline mutations in BRF1, a subunit of the RNA polymerase III transcription complex, and hereditary colorectal cancer[J]. Gastroenterology, 2018, 154(1): 181-194. e20. doi:10.3791/1135

Site-Directed Mutagenesis

Chen M, Zheng F, Yuan G, et al. Development of an infectious cell culture system for hepatitis C virus genotype 6a clinical isolate using a novel strategy and its sensitivity to direct-acting antivirals[J]. Frontiers in microbiology, 2018, 9. doi:10.3389/fmicb.2018.02950

Antibody Discovery Services

Xu Z, Zhou X, Chen G. Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation[J]. Medical science monitor: international medical journal of experimental and clinical research, 2019, 25: 984. doi: 10.12659/MSM.911910

High Throughput Gene Synthesis

Rai K M, Ghose K, Rai A, et al. Genome Engineering Tools in Plant Synthetic Biology[M]//Current Developments in Biotechnology and Bioengineering. Elsevier, 2019: 47-73. doi:10.1016/B978-0-444-64085-7.00003-4

Peptide Sequence Synthesis

Jiao X, Sun W, Zhang Y, et al. Exchanging the order of carotenogenic genes linked by porcine teschovirus-1 2A peptide enable to optimize carotenoid metabolic pathway in Saccharomyces cerevisiae[J]. RSC Advances, 2018, 8(61): 34967-34972. doi:10.1039/C8RA06510A

Lentiviral packaging

Zhou, K; Chen, J, Wu, J; Xu, Y… Tu, W; Yang, G; Jiang, S(2019)Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-Catenin Signaling Pathway Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Volume 27, Number 9. doi:10.3727/096504019X15579146061957